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Chise 🧬🧫🦠🔬💉🥼🥽

@sailorrooscout

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Superb! Studies show when administered as boosters, mono- and bivalent Omicron BA.4/BA.5-adapted vaccines ENHANCE neutralization breadth, and in a bivalent format, may also have the potential to confer protection to individuals with NO pre-existing immunity against SARS-CoV-2!🧵

Source: •Exposure to BA.4/BA.5 Spike glycoprotein drives pan-Omicron neutralization in vaccine-experienced humans and mice: biorxiv.org/content/10.110…

Researchers recently reported that breakthrough infections of vaccinated individuals with Omicron sublineages BA.1 and BA.2 were associated with distinct patterns of cross-neutralizing activity against SARS-CoV-2 variants of concern (VOCs). BA.2 breakthrough infection mediated

overall stronger cross-neutralization of BA.2 and its descendants (BA.2.12.1, BA.4, and BA.5) compared to BA.1 breakthrough infection. Here, researchers characterized the effect of Omicron BA.4/BA.5 S (spike) glycoprotein exposure on the magnitude and breadth of the

neutralizing antibody response upon breakthrough infection in vaccinated individuals and in mice upon booster vaccination. They showed that immune sera from triple mRNA-vaccinated individuals with subsequent Omicron BA.4/BA.5 breakthrough infection displayed broad AND robust

neutralizing activity against Omicron BA.1, BA.2, BA.2.12.1, and BA.4/BA.5. Administration of a prototypic BA.4/BA.5-adapted mRNA booster vaccine to mice following SARS-CoV-2 wild-type strain-based primary immunization was ALSO associated with similarly broad

neutralizing activity. Immunization of naïve mice with a bivalent mRNA vaccine (wild-type + Omicron BA.4/BA.5) induced strong and broad neutralizing activity against Omicron VOCs and previous variants.

These findings suggest that when administered as boosters, mono- and bivalent Omicron BA.4/BA.5-adapted vaccines may enhance neutralization breadth, and in a bivalent format may also have the potential to confer protection to individuals with no pre-existing immunity against

SARS-CoV-2. Chise, what does this all mean? Let’s break it down! READ ⬇️

While we are here, I recommend reading @Edward Nirenberg 🇺🇦’s breakdown of this study. He discusses the impact of other variants on the rise (like BA.2.75.2 or BQ.1.1 which ARE still sub-variants of Omicron) and these vaccines (“DON’T write the vaccines off.”) •twitter.com/enirenberg/sta…

Edward Nirenberg 🇺🇦

@ENirenberg

Sep 22View on Twitter

IMAGINE THAT Anyway: please get your boosters. Exposure to BA.4/BA.5 Spike glycoprotein drives pan-Omicron neutralization in vaccine-experienced humans and mice biorxiv.org/content/10.110…

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So, what can we reasonably grasp from this study? A couple of things. For one, bivalent boosters will SIGNIFICANTLY enhance broad protection against Omicron AND its sub-variants AND this includes transmission. From the study researchers:

Together these findings add to our current understanding on how vaccine boosters adapted to Omicron VOCs in a bivalent format shape immunity and suggest that exposure to Omicron BA.4/.5 S glycoprotein may confer heightened protection against the currently circulating and

potential future Omicron VOCs. Conclusion: “Our finding that immunization of naïve mice with the BNT162b2/BA.4/.5 bivalent vaccine elicits strong neutralizing antibody responses against the wild-type strain as well as Omicron and non-Omicron VOCs suggest that this bivalent

approach may confer broad protection to unvaccinated individuals who have not been previously infected with SARS-CoV-2.” •Exposure to BA.4/BA.5 Spike glycoprotein drives pan-Omicron neutralization in vaccine-experienced humans and mice: biorxiv.org/content/10.110…

Chise 🧬🧫🦠🔬💉🥼🥽

@sailorrooscout

Chise / Senior Scientist / Vaccine Research & Development / 🧬🧫🦠🔬💉/ 🏳️‍🌈 / @darkroastyeen 💍 / Opinions Are My Own

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