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Eric Topol

Eric Topol
@EricTopol

Jan 25
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A couple of weeks ago I reviewed the BA.5 bivalent booster data and concluded it has worked better than expected erictopol.substack.com/p/the-bivalent… Today there are 3 new reports that strongly reinforce that 1. Comparing bivalent vs original for protection vs hospitalizations & deaths

2. Superior neutralizing antibodies vs the new variants with marked immune evasion: XBB.1, BQ.1.1, BA.2.75 compared with the original booster (adds to 12 lab studies)
3. Higher protection vs symptomatic infections (against XBB.1.5, which has an extreme ° of immune escape) than has been seen for the original booster, for at least 3 months [Original booster vs Omicron lineages ≤ 30% protection, and short-lived]
The links to the 3 new studies 1.nejm.org/doi/full/10.10… 2. nejm.org/doi/full/10.10… 3. cdc.gov/mmwr/volumes/7… Note: —The control groups of these reports were vaccinated and boosted —The benefits were seen across all age groups 18+
Eric Topol

Eric Topol

@EricTopol
physician-scientist, author, editor https://t.co/vwstu2BYrC Ground Truths: https://t.co/YhatcCa3jA
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